Letrozole: Description of the Drug
Letrozole is an aromatase inhibitor primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. By lowering estrogen levels in the body, it effectively slows or stops the growth of certain types of breast tumors that require estrogen to grow.
Mechanism of Action
The description of the drug illustrates how letrozole works by inhibiting the aromatase enzyme, which is responsible for converting androgens into estrogens in peripheral tissues. This reduction in estrogen production leads to decreased stimulation of estrogen-sensitive tumors, making it a crucial component in breast cancer therapy.
Indications
Letrozole is indicated for:
- Treatment of early breast cancer in postmenopausal women who have undergone surgery.
- Adjuvant therapy following surgery and radiotherapy to prevent recurrence.
- Advanced breast cancer after other treatments have failed.
Dosing and Administration
The typical dosage of letrozole is 2.5 mg taken orally once daily. It can be administered with or https://letrozolebuy.com/prod/letrozol-zentiva-filmtabletten-2-5mg-100-stuck/ without food, but consistency in taking the medication at the same time each day is advisable for optimal results.
Side Effects
While letrozole is effective, potential side effects should be considered. Common adverse reactions include:
- Hot flashes
- Joint pain or stiffness
- Fatigue
- Nausea
- Bone density loss
Patients are encouraged to discuss any unusual symptoms with their healthcare provider, as some side effects may require medical attention.
Contraindications and Precautions
The description of the drug emphasizes that letrozole is contraindicated in premenopausal women due to its mechanism of action. Additionally, caution is advised for patients with a history of osteoporosis or fractures, as letrozole may further decrease bone mineral density.
Drug Interactions
Letrozole may interact with various medications. Patients should inform their doctors about all medications they are currently taking, including over-the-counter drugs and supplements, to avoid potential interactions that could affect treatment efficacy.
Conclusion
In summary, letrozole serves as a vital tool in managing certain types of breast cancer. Its ability to lower estrogen levels makes it essential for postmenopausal women battling hormone receptor-positive tumors. Understanding the description of the drug, including its mechanism, indications, and potential side effects, empowers patients and healthcare providers to make informed decisions regarding breast cancer treatment.